Side Effects and Toxicities of CAR T-Cell Therapy
CAR T-cell therapy can cause unique side effects due to intense immune activation. The most common is cytokine release syndrome (CRS), which occurs when activated immune cells release large amounts of inflammatory molecules.
Symptoms of CRS range from mild fever and fatigue to severe hypotension and organ dysfunction. Prompt recognition and treatment are essential for patient safety.
Neurological side effects, often referred to as immune effector cell–associated neurotoxicity syndrome (ICANS), may include confusion, headache, or seizures. These effects are usually temporary but require close monitoring.
Supportive care and standardized treatment protocols have significantly improved the safety of CAR T-cell therapy.
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